{ "name": "Registered human trials of a peptide delivered through skin", "description": "For every molecule, this table counts registered trials of delivery through skin. It shows the furthest phase, posted results and molecular weight. Molecules with no registered study are rows too.", "author": "HealthspanLedger", "edition": "2026.08", "version": "bcb8762b13b6", "page": "https://healthspanledger.com/guides/glp-1-microneedle-patches", "citeAs": "HealthspanLedger. Registered human trials of a peptide delivered through skin. Edition 2026.08 (version bcb8762b13b6). Derived from ClinicalTrials.gov API v2.0.5, US National Library of Medicine, retrieved 2026-08-12. Licensed CC BY 4.0. https://healthspanledger.com/guides/glp-1-microneedle-patches", "license": { "url": "https://creativecommons.org/licenses/by/4.0/", "name": "Creative Commons Attribution 4.0 International (CC BY 4.0)" }, "source": { "name": "ClinicalTrials.gov API v2.0.5, US National Library of Medicine", "url": "https://clinicaltrials.gov/data-api/api", "retrieved": "2026-08-12", "publisherLastUpdated": null, "license": "https://www.usa.gov/publicdomain/label/1.0/", "licenseName": "US Government work, public domain" }, "arrangement": "The underlying records are United States government work and carry no copyright. How this table selects, joins, labels and bounds them is ours, and that work is licensed CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/): reuse it, including commercially, and credit HealthspanLedger with a link to the page it came from.", "temporalCoverage": "2026-08-12", "measurementTechnique": "One registry search per name each molecule is filed under, unioned by NCT id. A study counts only where the registry's own title or an intervention name says the drug goes through skin; the matching word is stored per study so the decision can be audited. Registrations failing an authenticity check are quarantined before any count. Molecular weights are read from each molecule's PubChem compound record, which the registry does not carry.", "readThisFirst": [ "A registered study is not evidence that a drug works, and none of these molecules has an approved product that goes through skin.", "A zero in registered_transdermal_studies means the registry returned no study of that molecule delivered through skin, under the names searched. It is a real answer, not a gap.", "Four more molecules were searched and returned nothing at all: liraglutide, exenatide, dulaglutide, insulin. They have no row because they have no study, and their absence is recorded here instead.", "Sponsors submit and update registry records themselves. The National Library of Medicine does not check them before they appear.", "molecular_weight_g_per_mol and pubchem_cid come from PubChem, not from the trial registry. Every other column comes from the registry." ], "rows": [ { "molecule": "zolmitriptan", "molecule_name": "Zolmitriptan", "molecular_weight_g_per_mol": 287.36, "pubchem_cid": 60857, "is_glp1": false, "names_searched": "zolmitriptan", "registered_transdermal_studies": 2, "highest_phase": "PHASE3", "highest_phase_label": "Phase 3", "any_study_recruiting": false, "any_results_posted": true, "nct_ids": "NCT04066023; NCT02745392", "searches_that_failed": 0, "why_tracked": "The control at the small end. It is well under the 500 g/mol ceiling, so nothing about its size argues against a patch." }, { "molecule": "glucagon", "molecule_name": "Glucagon", "molecular_weight_g_per_mol": 3482.7, "pubchem_cid": 16132283, "is_glp1": false, "names_searched": "glucagon", "registered_transdermal_studies": 2, "highest_phase": "PHASE2", "highest_phase_label": "Phase 2", "any_study_recruiting": false, "any_results_posted": false, "nct_ids": "NCT01684956; NCT02459938", "searches_that_failed": 0, "why_tracked": "A peptide hormone of roughly GLP-1 size, and the closest thing to a like-for-like test of the same idea." }, { "molecule": "abaloparatide", "molecule_name": "Abaloparatide", "molecular_weight_g_per_mol": 3961, "pubchem_cid": 76943386, "is_glp1": false, "names_searched": "abaloparatide; BA058", "registered_transdermal_studies": 3, "highest_phase": "PHASE3", "highest_phase_label": "Phase 3", "any_study_recruiting": false, "any_results_posted": true, "nct_ids": "NCT04064411; NCT01674621; NCT04366726", "searches_that_failed": 0, "why_tracked": "The latest-stage peptide patch in this tracked set. A 511-person phase 3 ran it head to head against the same peptide injected, and posted its numbers." }, { "molecule": "semaglutide", "molecule_name": "Semaglutide", "molecular_weight_g_per_mol": 4113.58, "pubchem_cid": 56843331, "is_glp1": true, "names_searched": "semaglutide", "registered_transdermal_studies": 2, "highest_phase": "PHASE1", "highest_phase_label": "Phase 1", "any_study_recruiting": true, "any_results_posted": false, "nct_ids": "NCT07673900; NCT07539415", "searches_that_failed": 0, "why_tracked": "The molecule in Ozempic and Wegovy, and the one the patches are named after." }, { "molecule": "teriparatide", "molecule_name": "Teriparatide", "molecular_weight_g_per_mol": 4118, "pubchem_cid": 16133850, "is_glp1": false, "names_searched": "teriparatide", "registered_transdermal_studies": 6, "highest_phase": "PHASE2", "highest_phase_label": "Phase 2", "any_study_recruiting": false, "any_results_posted": true, "nct_ids": "NCT01011556; NCT00489918; NCT00535860; NCT01250145; NCT01935479; NCT01551602", "searches_that_failed": 0, "why_tracked": "The nearest match by weight. It sits within about 5 g/mol of semaglutide, so a patch carrying it is the closest test of the same physical problem." }, { "molecule": "tirzepatide", "molecule_name": "Tirzepatide", "molecular_weight_g_per_mol": 4813.53, "pubchem_cid": 166567236, "is_glp1": true, "names_searched": "tirzepatide", "registered_transdermal_studies": 0, "highest_phase": null, "highest_phase_label": null, "any_study_recruiting": false, "any_results_posted": false, "nct_ids": "", "searches_that_failed": 0, "why_tracked": "The molecule in Mounjaro and Zepbound, and the heaviest in the set." } ] }