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Long-acting amylin analogue (investigational) · safety
Cagrilintide side effects
The cagrilintide side effects reported most often are nausea, stomach and gut events overall and reactions where injected. The full list is below, with the cited trial report cited at the bottom of the page.
Trial reports describe stomach and gut effects as dose-related and clustered around the steps up.
Cagrilintide is a weekly shot in weight-loss studies. It copies amylin, a natural signal that helps you feel full after eating. Sellers offer unapproved cagrilintide for weight loss, sometimes paired with semaglutide under the name CagriSema.
A phase 2 trial found more average weight loss at higher doses. It has moved into phase 3 trials with semaglutide. Cagrilintide does not have FDA approval.
At a glance
Common reactions listed
4
Serious reactions listed
0
Boxed warning
No label exists
Strongest source
Human trial
Common reactions
The full list, as reported across the available trial evidence. There is no approved label to read frequency bands off, so these are the trials’ own figures.
| Reaction | Frequency |
|---|---|
| Nausea | Reported in 20–47% across trial doses (vs 18% placebo) |
| Gastrointestinal events overall (nausea, constipation, diarrhea) | Reported in 41–63% across trial doses (vs 32% placebo) |
| Injection-site reactions | Reported in trials |
| Decreased appetite | Reported in trials |
When to seek medical care
The trial report does not give a separate list of serious reactions. There is also no approved label. That gap does not mean serious reactions cannot happen. This compound has been studied in fewer people and for less time than an approved drug.
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What the 26-week trial can—and cannot—show
The page above comes from a dose-finding study with 706 people. It tested weekly doses of 0.3 mg · 0.6 mg · 1.2 mg · 2.4 mg · 4.5 mg. The study shows what happened during that window. It may miss rare or later problems.
This page preserves 4 common reactions and 0 serious entries from that report. A missing reaction is outside this bounded record; it is not a result that the reaction cannot occur.
Common questions
How long do cagrilintide side effects last, and do they go away?
The 26-week trial report does not establish a set number of days for any reaction. It records whether an event occurred during the study, not a reliable personal countdown for when it will stop.
What are the most common cagrilintide side effects?
Nausea, gastrointestinal events overall (nausea, constipation, diarrhea), injection-site reactions and decreased appetite — the table above has the rest, each with its frequency band and source.
Does cagrilintide have a boxed warning?
No, because a boxed warning is part of an FDA-approved label and cagrilintide has no approved label. That reflects what regulatory review has and has not covered, not a finding that serious risks were looked for and ruled out.
Can the cagrilintide dose be lowered if side effects are hard to tolerate?
That decision belongs to the prescribing clinician. No approved schedule exists for this compound, so there is no labeled framework for adjusting a dose. That leaves the prescriber as the only place the decision can sit.
Were hair loss, fatigue or constipation listed for cagrilintide?
In the 26-week report, constipation was listed; hair loss and fatigue were not. That is a statement about the paper’s recorded terms, not proof that an unlisted symptom cannot occur.
What should someone do about a serious cagrilintide reaction?
Contact a clinician promptly, and emergency services if symptoms are severe or getting worse quickly. The available sources do not list any reactions as separately serious. That means there is no early-warning list here—not that serious reactions are impossible.
Do the frequencies on this page mean the chance it happens to one person?
No. These figures describe groups in a study. A band shows how often a reaction appeared under that trial’s conditions. It cannot predict what will happen to one person.
Related
The schedule these reactions were recorded against, the comparisons, and the sourcing rules behind every grade on this page.
Cagrilintide research, dosing, and approval status
The cagrilintide trial dosing program, arm by arm
Cagrilintide vial and water to an exact amount
Mixing math for any vial, not just cagrilintide
Which other pages list diarrhea besides cagrilintide
Constipation across every page, not just cagrilintide
The nausea question separate from cagrilintide
The full index behind the cagrilintide page