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Combination · what has actually been studied
BPC-157 and TB-500 together
One study has given BPC-157 and TB-500 together, and it was done in rats. Adding the second peptide did nothing extra: the combined group did no better than either peptide on its own. No person has ever been given the pair in a published study, and neither peptide has an established human dose by itself.
Source: Biçer 2026 in rats, plus searches of ClinicalTrials.gov and PubMed run 2026-08-12
no human dose shown to work indirect evidence
What matters first
Has anyone tested the two together?
Once, and not in people. The study below is the only place in either index where both peptides went into the same subjects. It is set out in full, result included, because the result is the part that usually goes missing.
Achilles tendon repair in rats, four groups
In rats · 32 subjects · 4 weeks · injection into the belly cavity
- What was done
- 32 male rats of about 330 g had the Achilles tendon cut and repaired, then were split at random into four groups of eight: nothing, BPC-157, TB-500, or both
- Amounts given
- BPC-157 at 10 mcg/kg a day and TB-500 at 60 mcg/kg a day, every day for four weeks
- What it found
- TB-500 alone was the only group whose tendon took significantly more load before failing. Tissue scores improved in the TB-500 group and in the combined group. The combined group gained nothing over either peptide used alone, which the authors state plainly. They suggest the two may end up pulling the same lever.
Source: Biçer O, Adanir O, Güleryüz Y, Balci EC, Dinçel YM, Yenigün MY. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study. Jt Dis Relat Surg 2026;37(3):822-37 · retrieved 2026-08-12. Animal results do not carry a dose across to a person.
| Searched | Query | Records | Gave both |
|---|---|---|---|
| ClinicalTrials.gov | BPC-157 AND TB-500 | 0 | 0 |
| PubMed | BPC-157 AND (TB-500 OR thymosin beta 4) | 8 | 1 |
Both searches were run on 2026-08-12. The links re-run them live, so a newer study will show up there before it shows up here.
A search that returns records is not a search that returns trials. Nearly every hit here is a review article, which is one author summarizing other people’s work. These are the ones that are not:
- The 2026 rat Achilles tendon study set out above — the one experiment that gave both.
- A 2021 report of BPC-157 injected into knee joints. That one used BPC-157 alone.
Why these two get paired
The pitch is that one peptide repairs and the other builds blood supply, so together they should mend an injury faster. The rat study above is the only place that idea has been put to a test with both peptides in the same animals. It came back negative for the pair.
What each one was really studied as
Every figure below comes from that compound’s own published sources, with the citation attached. The gap line shows what stack protocols often leave unanswered.
Studied as
Where that stops
Studied as
Where that stops
If it came as one blend vial
Two separate vials are two separate sums, and the per-compound calculators already do those. A blend vial is a different object: both peptides sit in one liquid, so one draw carries both and the ratio was fixed by whoever filled it. The most-searched pairing for these two is 10 mg bpc-157 with 10 mg tb-500, so that is the vial the table describes.
| Water added | BPC-157 | TB-500 | Per U-100 unit |
|---|---|---|---|
| 2 mL | 5.00 mg/mL | 5.00 mg/mL | 50 mcg + 50 mcg |
| 3 mL | 3.33 mg/mL | 3.33 mg/mL | 33 mcg + 33 mcg |
| 5 mL | 2.00 mg/mL | 2.00 mg/mL | 20 mcg + 20 mcg |
Deterministic arithmetic: concentration = milligrams divided by water, and one U-100 unit is 0.01 mL. The vial strengths come from our own keyword harvest, where bpc-157 tb-500 20mg blend dosage draws 110 US searches a month. That is a record of what people look for, not a recommendation.
Set the syringe by one, and see what the other does
This is the part two separate calculators cannot show you. In a blend there is one volume and two peptides, so only one of them can be the number you choose. Pick that one below. The panel on the right reports what arrives with it.
The vial and water are filled in. You enter the amount you want to check.
What goes wrong with this pair
- The only study of the pair used rats, and gave the peptides into the belly cavity rather than under the skin.
- Its quantities were set per kilogram. BPC-157 at 10 mcg/kg works out near 0.8 mg for an 80 kg adult, which is a fraction of what a milligram-a-day schedule assumes.
- The FDA placed both substances in category 2 of its compounding list, meaning it does not have enough information to know whether they would cause harm in people.
- A nomination for each went before the same FDA compounding committee on 23 July 2026, one for ulcerative colitis and one for wound healing. A committee view is advice, not a change in legal status.
- TB-500 is banned by name under the World Anti-Doping Agency list at all times.
Common questions
What is the dose for bpc-157 and tb-500 together?
There is no answer to give. No trial has set one, so any figure you find was written by a seller or a forum, and this site does not repeat those. What is on this page instead is what each peptide was separately given at, in the units the papers used, and the arithmetic for a vial you already hold.
Why does every other page have a schedule and this one does not?
Because those schedules have nothing behind them. A number repeated across a hundred pages is still one unsourced number. The searches above show what exists, and they take a second to re-run.
Does the animal study settle it?
No, and it points the other way than most people expect. It found no gain from using both over using either one alone. It also ran in rats, over four weeks, at amounts set per kilogram and injected into the belly cavity. None of that transfers to a person and a vial.
Can the two be mixed in one syringe?
That is a question about the chemistry of two powders in one liquid, and no published stability work covers this pair. Separately from that, a pre-mixed vial locks the ratio, so mixing removes a choice rather than adding one.
Is a blend vial the same as buying bpc-157 and tb-500 separately?
No. Two vials keep the two amounts apart, and each one has its own calculator on this site. One blend vial ties them together at whatever ratio it was filled at. The table above shows what that costs you in control.
Is either one approved?
Neither. Both are sold as research compounds, neither has an approved label, and no pharmacy is preparing either from an approved medicine. That is true of each one alone, and even more so of the two together.
Keep reading
Every row above is read from the two records behind it. Each calculator opens on one compound’s own vial sizes, which is the sum to run when the two are bought separately.
Convert TB-500 to units, beyond the BPC-157 and TB-500 blend
BPC-157 vial and water to a draw, separate from BPC-157 and TB-500
The other pairs read the way BPC-157 and TB-500 is
What was tested for CJC-1295 and ipamorelin rather than BPC-157 and TB-500
What a BPC-157 and TB-500 draw carries at each unit
Mixing math for one vial, not the BPC-157 and TB-500 blend
The TB-500 page behind BPC-157 and TB-500
The full BPC-157 entry BPC-157 and TB-500 reads from
- Biçer O, Adanir O, Güleryüz Y, Balci EC, Dinçel YM, Yenigün MY. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study. Jt Dis Relat Surg 2026;37(3):822-37retrieved 2026-08-12indirect evidence
- Certain Bulk Drug Substances for Use in Compounding May Present Significant Safety Risks — FDA category 2 listretrieved 2026-08-12FDA label