Page last checked 2026-08-13

How-to · reconstitution

How to reconstitute Semax 10 mg

Put 1 mL of bacteriostatic water into the 10 mg Semax vial. That makes 10.00 mg/mL. A 6 mg dose is then 60.0 units on a U-100 syringe.

That volume is the one that lands the draw on a syringe line, so the reading can be checked by eye. More water makes a weaker mix and a bigger draw. Less water makes a stronger mix and a smaller one. The amount of Semax in the glass never changes. Only the number of marks it takes does.

What matters first

Water to add: 1 mL
Resulting strength: 10.00 mg/mL
Example 6 mg dose: 60.0 U-100 units

What is Semax?

Semax is a peptide seven amino acids long, copied from a short stretch of a stress hormone. It carries none of that hormone’s own activity.

Medically reviewed by Jennifer Montecillo, MD · non-practicing medical reviewerReviewed 2026-08-13open the primary sources

How much bacteriostatic water for a 10 mg Semax vial?

◆ Unique to the 10 mg vialU-100 example draws

Water added	Concentration	Per U-100 unit	Example: 6 mg =
1 mL	10.00 mg/mL	100 mcg	60.0 units
2 mL	5.00 mg/mL	50 mcg	120.0 unitswon’t fit

Straight arithmetic: concentration = 10 mg ÷ water, and 1 U-100 unit = 0.01 mL. The example column shows the math at 6 mg; it is not a dose recommendation.

Which volume to use is a practical choice rather than a dose. Pick the one that puts your draw somewhere you can actually read it on the syringe. The flags in the last column mark where that fails. “Hard to measure” means the draw is too small to judge by eye. “Won’t fit” means it is bigger than one U-100 syringe holds.

Semax 10 mg vial: how much water to add. Each row is what that amount draws on a U-100 syringe. 1 mL makes 10.00 mg/mL, or 100 mcg a unit, and 6 mg is 60 units. 2 mL makes 5.00 mg/mL, or 50 mcg a unit, and 6 mg is more than one barrel holds. The barrel drawn here is filled to 60 units, the draw at 1 mL. The sum is 10 mg divided by the water. One U-100 unit is 0.01 mL. — The 10 mg vial at 1 mL on a U-100 barrel. 6 mg fills to 60.0 units, at 10.00 mg/mL.

How many units is a documented dose from this vial?

The table above uses one worked example. These are the published quantities, converted into marks on a U-100 barrel at each water volume for a 10 mg vial. Where a quantity was never studied by injection, the row says so.

6 mg — studied in a trial

6 mg a day, in two courses of ten days separated by twenty days, into the nose. (110 patients at different stages after an ischemic stroke, mean age 58; the study also reported a brain-growth-factor marker in the blood rising alongside recovery scores).

Water added	Concentration	Draw
1 mL	10.00 mg/mL	60.0 units
2 mL	5.00 mg/mL	120.0 unitswon’t fit

limited human dataGusev EI, Martynov MY, Kostenko EV, Petrova LV, Bobyreva SN. [The efficacy of semax in the tretament of patients at different stages of ischemic stroke]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3 Vyp 2):61-68 — 110 patients, two ten-day courses of 6000 mcg a day separated by twenty days. Russian; read here through the English abstract indexed in PubMed · retrieved 2026-08-13

12 mg — studied in a trial

12 mg a day as a 1% solution, in two courses of ten days two weeks apart, into the nose. (27 patients; the report calls itself open-label. It states that Semax did not change the course of the disease, with a difference showing only on a quality-of-life total).

Water added	Concentration	Draw
1 mL	10.00 mg/mL	120.0 unitswon’t fit
2 mL	5.00 mg/mL	240.0 unitswon’t fit

limited human dataSerdiuk AV, Levitskii GN, Miasoedov NF, Skvortsova VI. [The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax]. Zh Nevrol Psikhiatr Im S S Korsakova. 2007;107(4):29-39 — 27 patients given 12 mg a day intranasally as a 1% solution in two ten-day courses. The abstract calls it open-label and reports that Semax did not influence the course of the disease. Russian; read through the indexed English abstract · retrieved 2026-08-13

The smaller Semax vial, where the thinner mix runs out of barrel

Two strengths are documented, and this is the smaller one. At the worked amount it contains one draw, and only one of the two water options fits a U-100 syringe.

3Read the full vial record — 3 notes

Why one of the two rows fails

The published worked amount is large relative to this vial. With more water, one draw exceeds the capacity of a U-100 syringe.

The tighter mix lands the plunger on a printed line with room to spare. On this vial that is the only workable choice, which is a narrower situation than the larger size faces.

One draw, against a course that ran for days

The study used the worked amount daily in two ten-day periods separated by a break. This vial contains one day at that amount.

That arithmetic is worth doing before buying rather than after, because the shortfall is not marginal. Covering the published course at this strength would take a row of vials rather than one.

It is also arithmetic about a product given as nasal drops from a licensed bottle, which this powder is not. The mass matches and nothing else about the two does.

What the smaller strength is actually good for

A vial this size suits somebody who wants to prepare a small amount once, at the tighter of the two volumes, and use it.

It does not suit anyone trying to reproduce what the published studies did. The larger strength sold alongside it is closer to that shape, and the page for it says how much closer.

Neither strength is a pharmacy size. Both come from research suppliers, and the amount printed on the label is the seller’s own claim rather than a figure any regulator checked.

How do you mix it, step by step?

Wipe both stoppers with an alcohol swab and let them dry.
Draw up the water volume you picked from the table.
Let the water run slowly down the inside wall of the Semax vial, rather than jetting it onto the powder.
Swirl gently until it dissolves. Shaking damages peptides.
Store it as the dispensing label directs. What happens after mixing differs by product — some labels direct against refrigerating the mixed solution at all.

What if your water volume is not on the table?

The table shows the offered water volumes. The calculator does the same arithmetic for any volume and any syringe, and shows its working line by line.

Open the Semax calculator →

Where to read next about Semax

The arithmetic on this page is only half the question. These are the pages that carry the other half.

How semax differs from the rest of its class

No published human dosing schedule was found for semax.

Every calculator on this site, semax and the rest

Every intermediate value is printed, for semax or any other vial.

Primary regulatory documents, including semax

Every URL was fetched and live on its retrieval date, semax or otherwise.

The other guides written like the semax ones

Water options, resulting concentrations and an example draw for each, with semax as context

2primary sources, each with the day we read it — open the documents used on this page