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How-to · reconstitution
In this example, 1 mL of bacteriostatic water in a 10 mg Survodutide vial gives 10.00 mg/mL. An example 4.8 mg amount is then 48.0 units on a U-100 syringe.
This example lands on a syringe line. More water makes a weaker mix and a bigger draw. Less water makes a stronger mix and a smaller one. The amount of Survodutide stays the same. Use the diluent and volume specified for your product; the arithmetic alone does not choose them.
| Water added | Concentration | Per U-100 unit | Example: 4.8 mg = |
|---|---|---|---|
| 1 mL | 10.00 mg/mL | 100 mcg | 48.0 units |
| 2 mL | 5.00 mg/mL | 50 mcg | 96.0 units |
Straight arithmetic: concentration = 10 mg ÷ liquid volume, and 1 U-100 unit = 0.01 mL. The example column shows the math at 4.8 mg; it is not a dose recommendation.
The table compares possible concentrations; it does not establish which diluent or volume suits your product. Follow its dispensing instructions.
“Hard to measure” means the example draw is below two U-100 units. “Won’t fit” means it exceeds this syringe’s capacity.
Survodutide is an experimental weekly injection being studied for weight loss and a liver disease called MASH. It acts on GLP-1 and glucagon signals.
The table above uses one worked example. These are the published quantities, converted into marks on a U-100 barrel at each listed liquid volume for a 10 mg vial. Where a quantity was never studied by injection, the row says so.
0.6–4.8 mg once weekly, under the skin. (phase 2 arms: 0.6, 2.4, 3.6 or 4.8 mg, reached by up to 20 weeks of escalation).
| Water added | Concentration | Draw, low to high |
|---|---|---|
| 1 mL | 10.00 mg/mL | 6.0 to 48.0 units |
| 2 mL | 5.00 mg/mL | 12.0 to 96.0 units |
Human trialle Roux CW et al. Glucagon and GLP-1 receptor dual agonist survodutide for obesity: dose-finding phase 2 trial. Lancet Diabetes Endocrinol 2024 (PMID 38330987) · retrieved 2026-08-20
Twice the powder makes this the milder of survodutide’s two problems: two doses rather than one, and neither listed water volume overruns the syringe.
On the smaller vial one of the two listed volumes cannot be drawn at all. Here both can, because the stronger solution keeps the dose inside one barrel.
Fitting the barrel does not establish that the product is safer or that this vial is a better purchase. It only answers whether the calculated liquid volume falls within the displayed scale.
The vial content divided by the example amount gives two complete doses before handling losses. Changing the entered amount changes that count. It is not a statement of how many appointments a purchased product will cover.
No product storage limit is assigned here, so the portion count does not establish how long it can be used.
At lower trial amounts, the same drug content divides into more theoretical portions. The count below applies only to the worked amount.
At the larger listed volume the plunger travels most of the way up the illustrated syringe for one dose. The reading fits the scale, but a higher entered amount could reach or exceed its limit.
The capacity flag helps identify that change before a result is mistaken for a usable instruction. Check the actual syringe capacity rather than assuming every device marked U-100 holds the same total volume.
The calculator lets you enter your product’s vial strength and mixing volume, then shows the arithmetic for your syringe.
Open the Survodutide calculator →The arithmetic on this page is only half the question. These are the pages that carry the other half.