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How-to · reconstitution
Put 1 mL of bacteriostatic water into the 10 mg Survodutide vial. That makes 10.00 mg/mL. A 4.8 mg dose is then 48.0 units on a U-100 syringe.
That volume is the one that lands the draw on a syringe line, so the reading can be checked by eye. More water makes a weaker mix and a bigger draw. Less water makes a stronger mix and a smaller one. The amount of Survodutide in the glass never changes. Only the number of marks it takes does.
Survodutide is an experimental weekly injection being studied for weight loss and a liver disease called MASH. It acts on GLP-1 and glucagon signals.
| Water added | Concentration | Per U-100 unit | Example: 4.8 mg = |
|---|---|---|---|
| 1 mL | 10.00 mg/mL | 100 mcg | 48.0 units |
| 2 mL | 5.00 mg/mL | 50 mcg | 96.0 units |
Straight arithmetic: concentration = 10 mg ÷ water, and 1 U-100 unit = 0.01 mL. The example column shows the math at 4.8 mg; it is not a dose recommendation.
Which volume to use is a practical choice rather than a dose. Pick the one that puts your draw somewhere you can actually read it on the syringe. The flags in the last column mark where that fails. “Hard to measure” means the draw is too small to judge by eye. “Won’t fit” means it is bigger than one U-100 syringe holds.
The table above uses one worked example. These are the published quantities, converted into marks on a U-100 barrel at each water volume for a 10 mg vial. Where a quantity was never studied by injection, the row says so.
0.6–4.8 mg once weekly, under the skin. (phase 2 arms: 0.6, 2.4, 3.6 or 4.8 mg, reached by up to 20 weeks of escalation).
| Water added | Concentration | Draw, low to high |
|---|---|---|
| 1 mL | 10.00 mg/mL | 6.0 to 48.0 units |
| 2 mL | 5.00 mg/mL | 12.0 to 96.0 units |
Human trialle Roux CW et al. Glucagon and GLP-1 receptor dual agonist survodutide for obesity: dose-finding phase 2 trial. Lancet Diabetes Endocrinol 2024 (PMID 38330987) · retrieved 2026-08-20
Twice the powder makes this the milder of survodutide’s two problems: two doses rather than one, and neither listed water volume overruns the syringe.
On the smaller vial one of the two listed volumes cannot be drawn at all. Here both can, because the stronger solution keeps the dose inside one barrel.
It is the clearest case on the site of a larger vial being the safer buy rather than the more wasteful one.
Two doses is the whole of it. People buy the larger vial expecting a month of a weekly compound and get half of that. The studied amounts sit unusually close to the vial size.
No published source says how long the mixed solution keeps, so only the dose count can be calculated.
At lower trial amounts, the same vial lasts longer. The count below applies only to the worked amount.
At the larger listed volume the plunger travels most of the way up the syringe for one dose. That is comfortable to read and leaves nothing spare.
It is also why the flags in the table matter more here than anywhere else. The margin between a dose that fits and one that does not is thin.
The table shows the offered water volumes. The calculator does the same arithmetic for any volume and any syringe, and shows its working line by line.
Open the Survodutide calculator →The arithmetic on this page is only half the question. These are the pages that carry the other half.