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Reconstitution · Survodutide
Pick the vial, the water you added and the dose. Get the exact draw in units for the syringe in your hand.
Step 1 of 4
This vial holds 10 mg in total.
U-100 insulin syringe · 1 mL · lines every 2 units · 1 unit = 0.01 mL
96.0 units on a U-100 insulin syringe · 1 mL · lines every 2 units, which is 0.96 milliliters. The draw lands on a syringe line.
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Survodutide is an experimental weekly injection being studied for weight loss and a liver disease called MASH. It acts on GLP-1 and glucagon signals. Sellers offer unapproved survodutide to people seeking weight loss.
A phase 2 trial reported average weight loss over 46 weeks. Larger phase 3 trials are underway, and survodutide does not have FDA approval.
Each row starts with the same 10 mg vial and changes only the amount of water. More water makes the mixture less concentrated, so the same dose uses more syringe units.
| Water added | Concentration | Per U-100 unit | Draw for 4.8 mg | Nearest syringe line |
|---|---|---|---|---|
| 1 mL | 10.00 mg/mL | 100.0 mcg | 48.0 u · 0.480 mL | exactly 48 u |
| 2 mL | 5.00 mg/mL | 50.0 mcg | 96.0 u · 0.960 mL | exactly 96 u |
The vial, water and dose shown here are the calculator’s starting example for Survodutide. Replace them with your own values. Every result in the table is calculated from those inputs.
The highest amount survodutide’s trials gave people is close to everything the smaller vial holds. That one fact drives every mixing decision on this page, and it turns the usual advice upside down.
Mix the smaller vial into the larger water volume and a dose at the top of the studied range no longer fits a U-100 syringe. Not by a little. It needs the best part of two full barrels.
The worked table says so rather than hiding it. A row reporting that the draw will not fit is more useful than a row quietly assuming a second syringe.
Everywhere else on this site, adding water is the safe move. It stretches a small dose across more marks and makes rounding matter less. Survodutide inverts that.
Its doses are already large, so extra water pushes them off the end of the barrel instead of onto a readable part of it. This is the compound where a rule of thumb learned on a GLP-1 vial does the opposite of what you expect.
At the top of the studied range, even the larger vial holds only a couple of doses. People buy it expecting a month and get two weeks.
The vial-life tab counts this out instead of estimating it. That arithmetic is obvious once seen and easy to get wrong in your head, because the milligrams on the vial and the milligrams in the dose sit unusually close together.
The figure this page opens on is the highest arm of a dose-finding trial. That trial reported a result for every arm it ran, which is rare on this site. So the whole ladder is visible at once, and what it shows is that the last step up was the smallest.
Read the arms in order on the page. The step from the lowest arm to the next is large. After that they sit close together, and the gap between the top two is smaller still.
The trial’s own label on this page describes two stretches. A long climb, and then a longer stretch holding steady at the top of it.
Mix 10 mg into 2 mL and one U-100 unit carries 50.0 mcg. The table shows how much peptide is in each numbered syringe line. These are conversion examples, not suggested doses.
| U-100 line | Volume | Mass (mcg) | Mass (mg) |
|---|---|---|---|
| 10 u | 0.10 mL | 500 mcg | 0.5 mg |
| 20 u | 0.20 mL | 1,000 mcg | 1 mg |
| 30 u | 0.30 mL | 1,500 mcg | 1.5 mg |
| 40 u | 0.40 mL | 2,000 mcg | 2 mg |
| 50 u | 0.50 mL | 2,500 mcg | 2.5 mg |
| 60 u | 0.60 mL | 3,000 mcg | 3 mg |
| 70 u | 0.70 mL | 3,500 mcg | 3.5 mg |
| 80 u | 0.80 mL | 4,000 mcg | 4 mg |
| 90 u | 0.90 mL | 4,500 mcg | 4.5 mg |
| 100 u | 1.00 mL | 5,000 mcg | 5 mg |
The math is only one part of the question. These guides cover the compound, published doses, side effects, mixing steps and supplies.
Survodutide dosing evidence, without an approved schedule
Survodutide — class, half-life and regulatory standing
Every reaction on the survodutide page, with its frequency
What each water volume does to the 10 mg survodutide vial
Reconstituting survodutide at 5 mg, step by step
Check the same draw on a vial that is not survodutide