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How-to · reconstitution
Put 1 mL of bacteriostatic water into the 5 mg Survodutide vial. That makes 5.00 mg/mL. A 4.8 mg dose is then 96.0 units on a U-100 syringe.
That volume is the one that lands the draw on a syringe line, so the reading can be checked by eye. More water makes a weaker mix and a bigger draw. Less water makes a stronger mix and a smaller one. The amount of Survodutide in the glass never changes. Only the number of marks it takes does.
Survodutide is an experimental weekly injection being studied for weight loss and a liver disease called MASH. It acts on GLP-1 and glucagon signals.
| Water added | Concentration | Per U-100 unit | Example: 4.8 mg = |
|---|---|---|---|
| 1 mL | 5.00 mg/mL | 50 mcg | 96.0 units |
| 2 mL | 2.50 mg/mL | 25 mcg | 192.0 unitswon’t fit |
Straight arithmetic: concentration = 5 mg ÷ water, and 1 U-100 unit = 0.01 mL. The example column shows the math at 4.8 mg; it is not a dose recommendation.
Which volume to use is a practical choice rather than a dose. Pick the one that puts your draw somewhere you can actually read it on the syringe. The flags in the last column mark where that fails. “Hard to measure” means the draw is too small to judge by eye. “Won’t fit” means it is bigger than one U-100 syringe holds.
The table above uses one worked example. These are the published quantities, converted into marks on a U-100 barrel at each water volume for a 5 mg vial. Where a quantity was never studied by injection, the row says so.
0.6–4.8 mg once weekly, under the skin. (phase 2 arms: 0.6, 2.4, 3.6 or 4.8 mg, reached by up to 20 weeks of escalation).
| Water added | Concentration | Draw, low to high |
|---|---|---|
| 1 mL | 5.00 mg/mL | 12.0 to 96.0 units |
| 2 mL | 2.50 mg/mL | 24.0 to 192.0 unitswon’t fit |
Human trialle Roux CW et al. Glucagon and GLP-1 receptor dual agonist survodutide for obesity: dose-finding phase 2 trial. Lancet Diabetes Endocrinol 2024 (PMID 38330987) · retrieved 2026-08-20
The worked amount uses nearly the whole vial. With the larger water amount, the draw exceeds the capacity of a U-100 syringe.
The vial holds one full draw at the worked amount, and the remainder is not enough for a second.
It also settles the storage question by removing it: a vial that empties immediately never reaches the point where how long it keeps would matter.
The strength you mix to is therefore the only decision on this page that changes anything. There is no second dose to plan around and no supply to ration.
Spread this vial through the larger listed volume and the dose needs the best part of two full barrels. The table flags the row rather than hiding it.
Everywhere else on this site adding water is the cautious choice. Here it is the choice that makes one injection into two draws.
Survodutide’s studied amounts are large in milligrams, so the usual instinct to dilute works against you. The stronger mix is the one that keeps a dose inside a single syringe.
That rule of thumb holds for this compound and fails for most of its neighbors. It belongs on this page rather than in a general guide.
The table shows the offered water volumes. The calculator does the same arithmetic for any volume and any syringe, and shows its working line by line.
Open the Survodutide calculator →The arithmetic on this page is only half the question. These are the pages that carry the other half.