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How-to · reconstitution
In this example, 1 mL of bacteriostatic water in a 5 mg Survodutide vial gives 5.00 mg/mL. An example 4.8 mg amount is then 96.0 units on a U-100 syringe.
This example lands on a syringe line. More water makes a weaker mix and a bigger draw. Less water makes a stronger mix and a smaller one. The amount of Survodutide stays the same. Use the diluent and volume specified for your product; the arithmetic alone does not choose them.
| Water added | Concentration | Per U-100 unit | Example: 4.8 mg = |
|---|---|---|---|
| 1 mL | 5.00 mg/mL | 50 mcg | 96.0 units |
| 2 mL | 2.50 mg/mL | 25 mcg | 192.0 unitswon’t fit |
Straight arithmetic: concentration = 5 mg ÷ liquid volume, and 1 U-100 unit = 0.01 mL. The example column shows the math at 4.8 mg; it is not a dose recommendation.
The table compares possible concentrations; it does not establish which diluent or volume suits your product. Follow its dispensing instructions.
“Hard to measure” means the example draw is below two U-100 units. “Won’t fit” means it exceeds this syringe’s capacity.
Survodutide is an experimental weekly injection being studied for weight loss and a liver disease called MASH. It acts on GLP-1 and glucagon signals.
The table above uses one worked example. These are the published quantities, converted into marks on a U-100 barrel at each listed liquid volume for a 5 mg vial. Where a quantity was never studied by injection, the row says so.
0.6–4.8 mg once weekly, under the skin. (phase 2 arms: 0.6, 2.4, 3.6 or 4.8 mg, reached by up to 20 weeks of escalation).
| Water added | Concentration | Draw, low to high |
|---|---|---|
| 1 mL | 5.00 mg/mL | 12.0 to 96.0 units |
| 2 mL | 2.50 mg/mL | 24.0 to 192.0 unitswon’t fit |
Human trialle Roux CW et al. Glucagon and GLP-1 receptor dual agonist survodutide for obesity: dose-finding phase 2 trial. Lancet Diabetes Endocrinol 2024 (PMID 38330987) · retrieved 2026-08-20
The worked amount uses nearly the whole vial. With the larger water amount, the draw exceeds the capacity of a U-100 syringe.
The vial holds one full draw at the worked amount, and the remainder is not enough for a second.
The portion count does not classify the container as single-dose or establish how it should be stored. Those are properties of the dispensed product and its instructions, not the result of dividing two numbers.
The concentration examples explain why different liquid volumes produce different readings. They do not establish a mixing method or permit saving, combining or using the remainder.
Spread this vial through the larger listed volume and the dose needs the best part of two full barrels. The table flags the row rather than hiding it.
More liquid makes the calculated draw larger. The warning means that this example exceeds the illustrated equipment; it is not an instruction to split an injection across syringes.
At the same worked amount, the more concentrated example uses less liquid and fits the illustrated barrel. The less concentrated example requires more liquid than that barrel can hold.
This is a comparison of arithmetic inputs, not a general instruction to use less water. Product-specific directions are needed before a calculation can be applied to an actual preparation.
The calculator lets you enter your product’s vial strength and mixing volume, then shows the arithmetic for your syringe.
Open the Survodutide calculator →The arithmetic on this page is only half the question. These are the pages that carry the other half.