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Reconstitution · KPV
Pick the vial, the water you added and the dose. Get the exact draw in units for the syringe in your hand.
Step 1 of 4
This vial holds 10,000 mcg in total.
U-100 insulin syringe · 1 mL · lines every 2 units · 1 unit = 0.01 mL
15.0 units on a U-100 insulin syringe · 1 mL · lines every 2 units, which is 0.15 milliliters. The nearest syringe line is 16 units.
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KPV is three amino acids — lysine, proline, valine. They are the tail end of the hormone that controls skin pigment. It is sold for gut inflammation, and for eczema and other inflamed skin.
The interest behind that is real but narrow. In mice given colitis chemically, and in colon cells in a dish, it quietens inflammatory signaling. The FDA states it has found no data on any person receiving it, by any route.
No completed controlled human trial has shown which dose works for KPV. There is no study-backed human dosing program to publish. Animal quantities are not converted into a human recommendation.
no human dose shown to work
Each row starts with the same 10 mg vial and changes only the amount of water. More water makes the mixture less concentrated, so the same dose uses more syringe units.
| Water added | Concentration | Per U-100 unit | Draw for 500 mcg | Nearest syringe line |
|---|---|---|---|---|
| 2 mL | 5.00 mg/mL | 50.0 mcg | 10.0 u · 0.100 mL | exactly 10 u |
| 3 mL | 3.33 mg/mL | 33.3 mcg | 15.0 u · 0.150 mL | 16 u · 6.7% off |
The vial, water and dose shown here are the calculator’s starting example for KPV. Replace them with your own values. Every result in the table is calculated from those inputs.
The FDA states it has found no human exposure data for KPV by any route. The arithmetic below is exact, and it applies to an amount that has never gone into a person in a study.
Three residues is as short as any molecule on this site. The page makes the practical point: a peptide that short is cheap to fake and hard to tell apart by looking at it.
Every figure on this page starts from the strength printed on a vial. Here that print is a seller’s claim with less standing behind it than usual.
The work behind KPV is chemically induced gut inflammation in mice and cultured gut cells. Current effort is still on getting the peptide through a rodent gut intact, which sits several stages before an amount for a person.
Oral, topical and injected forms all sell under this one name. They do not deliver comparable amounts, so nothing quoted for one describes another.
The conventional amount lands between roughly ten and thirty units across this page’s vials and volumes. That is a forgiving part of the barrel, where rounding hardly matters.
It is a property of the vial sizes people happen to sell. It is not a signal that the amount is right, and the ease of the measurement is the least important thing on this page.
Most empty records here are empty because a search came back with nothing. That is an argument from silence, however well the search was run. This one is different. A federal agency states in its own words that it found no human exposure data by any route, and it published the working.
The agency’s briefing document is specific. The party asking for this substance cited nine references, and not one was a study of the peptide given to a person.
The preparation put forward for compounding was a topical cream or gel. That is what the request covered. The uses examined were wound healing and inflammation.
The mouse work is oral. The peptide goes into drinking water, or down a tube inside particles built to protect it through the gut. The figure everyone quotes from cell work is a concentration in a dish.
Three residues, and an old sequence. In its bare form it is effectively unpatentable. That removes the reason anyone would fund the toxicology package a first study in people needs.
Mix 10 mg into 3 mL and one U-100 unit carries 33.3 mcg. The table shows how much peptide is in each numbered syringe line. These are conversion examples, not suggested doses.
| U-100 line | Volume | Mass (mcg) | Mass (mg) |
|---|---|---|---|
| 10 u | 0.10 mL | 333 mcg | 0.333 mg |
| 20 u | 0.20 mL | 667 mcg | 0.667 mg |
| 30 u | 0.30 mL | 1,000 mcg | 1 mg |
| 40 u | 0.40 mL | 1,333 mcg | 1.333 mg |
| 50 u | 0.50 mL | 1,667 mcg | 1.667 mg |
| 60 u | 0.60 mL | 2,000 mcg | 2 mg |
| 70 u | 0.70 mL | 2,333 mcg | 2.333 mg |
| 80 u | 0.80 mL | 2,667 mcg | 2.667 mg |
| 90 u | 0.90 mL | 3,000 mcg | 3 mg |
| 100 u | 1.00 mL | 3,333 mcg | 3.333 mg |
The math is only one part of the question. These guides cover the compound, published doses, side effects, mixing steps and supplies.