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Endogenous nonapeptide (research compound) · safety

DSIP side effects

Also called delta sleep-inducing peptide or delta sleep peptide.

The dsip side effects reported most often are headache. The full list is below, with the cited trial report cited at the bottom of the page.

The sources describe these effects in relation to the dose and to the early weeks.

DSIP stands for delta sleep-inducing peptide. It is nine amino acids long, and it was recovered in 1977 from the blood of rabbits put into deep sleep electrically. It is sold for insomnia and for deeper sleep.

It has more human research than many peptides sold this way, but the evidence is still thin. European groups gave it during the 1980s to people with insomnia and to people in alcohol and opiate withdrawal, and reported improved sleep. The studies were small, mostly open label, used intravenous dosing and never led to an approval.

Further down: the full list with frequencies · when to get medical help · questions

Medically reviewed by Jennifer Montecillo, MD · non-practicing medical reviewerReviewed 2026-08-12open the primary sources

At a glance

Common reactions listed

1

Serious reactions listed

0

Boxed warning

No label exists

Strongest source

limited human data

The counts show how many distinct reactions the cited trial report names. The percentages show how often a reaction appeared in a study group, not the chance that it will happen to you.

Common reactions

The full list, as reported across the available trial evidence. There is no approved label to read frequency bands off, so these are the trials’ own figures.

◆ Common reactionstrial-reported
ReactionFrequency
HeadacheReported by a few of 107 inpatients treated for alcohol or opiate withdrawal — no incidence figure was published

limited human dataEvery reaction above comes from a cited trial. These are study findings, not instructions on what to take.

When to seek medical care

The trial report does not give a separate list of serious reactions. There is also no approved label. That gap does not mean serious reactions cannot happen. This compound has been studied in fewer people and for less time than an approved drug.

EmergencySome symptoms should not wait for an appointment. Call emergency services (911 in the US) if they are severe, getting worse fast, or involve trouble breathing, chest pain, fainting or confusion.

1Read deeperTiming, evidence limits, and product context

When these effects tend to occur

The cited evidence describes these effects in relation to the dose and to the early period of taking it, rather than as a constant background throughout.

When a study reports how side effects changed over time, it describes the group as a whole. It cannot predict one person’s experience.

Common questions

How long do dsip side effects last, and do they go away?

The sources do not commit to a set number of days. What they describe is a pattern — reactions cluster after you start and after each increase, then ease while the dose is held steady. Any page quoting an exact number of days is quoting something the sources do not say.

What are the most common dsip side effects?

Headache — the table above has the rest, each with its frequency band and source.

Does dsip have a boxed warning?

No, because a boxed warning is part of an FDA-approved label and dsip has no approved label. That reflects what regulatory review has and has not covered, not a finding that serious risks were looked for and ruled out.

Can the dsip dose be lowered if side effects are hard to tolerate?

That decision belongs to the prescribing clinician. No approved schedule exists for this compound, so there is no labeled framework for adjusting a dose. That leaves the prescriber as the only place the decision can sit.

Does dsip cause hair loss?

Hair loss is not among the reactions listed on this page for dsip, because the cited trial report cited here does not carry it. Anything missing from the tables is outside what can be sourced here rather than ruled out, and a symptom that worries you belongs with a clinician.

Is fatigue a listed dsip side effect?

No — the cited trial report cited here does not list it. That describes what was reported, not proof that the symptom cannot happen.

Is constipation a listed dsip side effect?

Not separately. If a source groups stomach and gut events together, this page keeps that group intact. It does not invent named reactions the source never listed.

What should someone do about a serious dsip reaction?

Contact a clinician promptly, and emergency services if symptoms are severe or getting worse quickly. The available sources do not list any reactions as separately serious. That means there is no early-warning list here—not that serious reactions are impossible.

Do the frequencies on this page mean the chance it happens to one person?

No. These figures describe groups in a study. A band shows how often a reaction appeared under that trial’s conditions. It cannot predict what will happen to one person.

Related

The schedule these reactions were recorded against, the comparisons, and the sourcing rules behind every grade on this page.

DSIP — class, half-life and regulatory standing

No approved brand name is listed for DSIP.

DSIP concentration and dose-draw tool

The concentration in mg/mL for every DSIP vial and water pairing, printed in full.

Check the same draw on a vial that is not DSIP

Any vial at all, DSIP among them, with the arithmetic shown rather than hidden.

Where DSIP stands with the regulator, and when

Approval status, proceedings and the date attached to each, with DSIP as one example

Every compound guide, DSIP and the rest

Class, approval status and strongest available source for every compound, with DSIP as one example

Why some DSIP values are missing on purpose

An absent value means no source carries one, including DSIP

Questions readers ask

How long does it take for DSIP to work?

The studies dosed it right before sleep and scored the night that followed, so none of them timed an onset. One gave a single injection; the other gave six across a week, then tracked sleep for a further week.

Both were small, mostly open rather than controlled, and both are forty years old.

Does DSIP make you tired?

Nobody has measured sleepiness in a healthy person, so that use has no answer. The 1980s studies enrolled chronic insomniacs and 107 inpatients coming off alcohol and opiates.

The name records an experiment, not a shown human effect. Researchers recovered the peptide in 1977 from rabbit brain blood during electrically induced slow-wave sleep.

Does DSIP peptide really work?

No controlled trial has established that it induces sleep. Two small insomnia studies reported sleep normalizing, and the largest human series scored withdrawal symptoms rather than sleep.

FDA listed it, as emideltide, for a compounding-committee review on 24 July 2026. That review asks whether pharmacists may compound it at all, and it is not an approval.

Who should not use DSIP?

No regulator anywhere has licensed this peptide, so no label exists to carry that list. The people who did receive it were hospital inpatients in alcohol or opiate withdrawal, and insomniacs aged 29 to 83.

One gap sits under all of it. Every human dose went into a vein, scaled per kilogram, and no study used an injection under the skin.

1primary source, each with the day we read it — open the documents used on this page