Page last checked 2026-08-12

How-to · reconstitution

How to reconstitute Sermorelin 6 mg

Put 3 mL of bacteriostatic water into the 6 mg Sermorelin vial. That makes 2.00 mg/mL. A 500 mcg dose is then 25.0 units on a U-100 syringe.

That volume is the one that lands the draw on a syringe line, so the reading can be checked by eye. More water makes a weaker mix and a bigger draw. Less water makes a stronger mix and a smaller one. The amount of Sermorelin in the glass never changes. Only the number of marks it takes does.

What matters first

Water to add: 3 mL
Resulting strength: 2.00 mg/mL
Example 500 mcg dose: 25.0 U-100 units

What is Sermorelin?

Sermorelin is the first 29 amino acids of the hormone that prompts growth hormone release. It is the shortest piece that still does the job at the pituitary.

Medically reviewed by Jennifer Montecillo, MD · non-practicing medical reviewerReviewed 2026-08-12open the primary sources

How much bacteriostatic water for a 6 mg Sermorelin vial?

◆ Unique to the 6 mg vialU-100 example draws

Water added	Concentration	Per U-100 unit	Example: 500 mcg =
2 mL	3.00 mg/mL	30 mcg	16.7 units
3 mL	2.00 mg/mL	20 mcg	25.0 units

Straight arithmetic: concentration = 6 mg ÷ water, and 1 U-100 unit = 0.01 mL. The example column shows the math at 500 mcg; it is not a dose recommendation.

Which volume to use is a practical choice rather than a dose. Pick the one that puts your draw somewhere you can actually read it on the syringe. The flags in the last column mark where that fails. “Hard to measure” means the draw is too small to judge by eye. “Won’t fit” means it is bigger than one U-100 syringe holds.

Sermorelin 6 mg vial: how much water to add. Each row is what that amount draws on a U-100 syringe. 2 mL makes 3.00 mg/mL, or 30 mcg a unit, and 500 mcg is 16.7 units. 3 mL makes 2.00 mg/mL, or 20 mcg a unit, and 500 mcg is 25 units. The barrel drawn here is filled to 25 units, the draw at 3 mL. The sum is 6 mg divided by the water. One U-100 unit is 0.01 mL. — The 6 mg vial at 3 mL on a U-100 barrel. 500 mcg fills to 25.0 units, at 2.00 mg/mL.

How many units is a documented dose from this vial?

The table above uses one worked example. These are the published quantities, converted into marks on a U-100 barrel at each water volume for a 6 mg vial. Where a quantity was never studied by injection, the row says so.

0.5–1 mg — studied in a trial

0.5–1 mg twice daily for 14 days in healthy men of about 68, under the skin. Only the 1 mg arm raised 24-hour growth hormone and IGF-I significantly above the men’s own baseline.

Water added	Concentration	Draw, low to high
2 mL	3.00 mg/mL	16.7 to 33.3 units
3 mL	2.00 mg/mL	25.0 to 50.0 units

Human trialCorpas E, Harman SM, Piñeyro MA, Roberson R, Blackman MR. Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men. J Clin Endocrinol Metab 1992;75(2):530-5 · retrieved 2026-08-12

200–300 mcg — reported, not studied

200–300 mcg once daily, as a flat quantity, under the skin. Where every clinical number above was set per kilogram of body weight, and the largest of those trials ran in children rather than in anyone choosing it.

Water added	Concentration	Draw, low to high
2 mL	3.00 mg/mL	6.7 to 10.0 units
3 mL	2.00 mg/mL	10.0 to 15.0 units

indirect evidenceDominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, Ruchała M. The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration. Front Endocrinol 2026 — tabulates self-reported online dosing patterns beside the clinical doses, stating the reported values must not be read as clinically validated, regulatory-approved or safe · retrieved 2026-08-12

A vial size a pharmacy chose, not a manufacturer

This pharmacy fill contains twelve worked doses. Only the larger water option produces a whole-number syringe reading.

3Read the full vial record — 3 notes

A fifth more powder is enough to break a whole number

Against the smallest vial in this family the difference is slight. It is still enough to move the draw off a syringe line at the smaller volume.

That is the practical consequence of odd fill sizes. They do not make a vial worse; they make the reading land where no line is printed.

Twelve draws, and one clean way to take them

Only the larger listed volume puts the reading on a graduation here. The smaller one leaves the plunger between two, at a draw where a mark is a small share of the dose.

Both exact figures stay visible so the difference between the two options is easy to compare.

No window figure to set against twelve

No published source gives a storage window for the mixed vial. Twelve is a dose count, not twelve weeks of use.

That is a long time for a compounded solution to sit. No cited source confirms that the mixture remains usable for the full calculated period.

How do you mix it, step by step?

Wipe both stoppers with an alcohol swab and let them dry.
Draw up the water volume you picked from the table.
Let the water run slowly down the inside wall of the Sermorelin vial, rather than jetting it onto the powder.
Swirl gently until it dissolves. Shaking damages peptides.
Store it as the dispensing label directs. What happens after mixing differs by product — some labels direct against refrigerating the mixed solution at all.

What if your water volume is not on the table?

The table shows the offered water volumes. The calculator does the same arithmetic for any volume and any syringe, and shows its working line by line.

Open the Sermorelin calculator →

Where to read next about Sermorelin

The arithmetic on this page is only half the question. These are the pages that carry the other half.

How strong the evidence is for sermorelin

The strongest source for sermorelin is a foreign approval or thin human data.

Mixing math for any vial, not just sermorelin

One calculator for every vial on this site, with sermorelin as one example

What the FDA has published on sermorelin

What has been decided, and what has only been proposed, including Sermorelin

The other guides written like the sermorelin ones

Water options, resulting concentrations and an example draw for each, with sermorelin as context

4primary sources, each with the day we read it — open the documents used on this page