Page last checked 2026-08-12

How-to · reconstitution

How to reconstitute Sermorelin 9 mg

Put 2 mL of bacteriostatic water into the 9 mg Sermorelin vial. That makes 4.50 mg/mL. A 500 mcg dose is then 11.1 units on a U-100 syringe.

More water makes a weaker mix and a bigger draw. Less water makes a stronger mix and a smaller one. The amount of Sermorelin in the glass never changes. Only the number of marks it takes does.

What matters first

Water to add: 2 mL
Resulting strength: 4.50 mg/mL
Example 500 mcg dose: 11.1 U-100 units

What is Sermorelin?

Sermorelin is the first 29 amino acids of the hormone that prompts growth hormone release. It is the shortest piece that still does the job at the pituitary.

Medically reviewed by Jennifer Montecillo, MD · non-practicing medical reviewerReviewed 2026-08-12open the primary sources

How much bacteriostatic water for a 9 mg Sermorelin vial?

◆ Unique to the 9 mg vialU-100 example draws

Water added	Concentration	Per U-100 unit	Example: 500 mcg =
2 mL	4.50 mg/mL	45 mcg	11.1 units
3 mL	3.00 mg/mL	30 mcg	16.7 units

Straight arithmetic: concentration = 9 mg ÷ water, and 1 U-100 unit = 0.01 mL. The example column shows the math at 500 mcg; it is not a dose recommendation.

Which volume to use is a practical choice rather than a dose. Pick the one that puts your draw somewhere you can actually read it on the syringe. The flags in the last column mark where that fails. “Hard to measure” means the draw is too small to judge by eye. “Won’t fit” means it is bigger than one U-100 syringe holds.

Sermorelin 9 mg vial: how much water to add. Each row is what that amount draws on a U-100 syringe. 2 mL makes 4.50 mg/mL, or 45 mcg a unit, and 500 mcg is 11.1 units. 3 mL makes 3.00 mg/mL, or 30 mcg a unit, and 500 mcg is 16.7 units. The barrel drawn here is filled to 11.1 units, the draw at 2 mL. The sum is 9 mg divided by the water. One U-100 unit is 0.01 mL. — The 9 mg vial at 2 mL on a U-100 barrel. 500 mcg fills to 11.1 units, at 4.50 mg/mL.

How many units is a documented dose from this vial?

The table above uses one worked example. These are the published quantities, converted into marks on a U-100 barrel at each water volume for a 9 mg vial. Where a quantity was never studied by injection, the row says so.

0.5–1 mg — studied in a trial

0.5–1 mg twice daily for 14 days in healthy men of about 68, under the skin. Only the 1 mg arm raised 24-hour growth hormone and IGF-I significantly above the men’s own baseline.

Water added	Concentration	Draw, low to high
2 mL	4.50 mg/mL	11.1 to 22.2 units
3 mL	3.00 mg/mL	16.7 to 33.3 units

Human trialCorpas E, Harman SM, Piñeyro MA, Roberson R, Blackman MR. Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men. J Clin Endocrinol Metab 1992;75(2):530-5 · retrieved 2026-08-12

200–300 mcg — reported, not studied

200–300 mcg once daily, as a flat quantity, under the skin. Where every clinical number above was set per kilogram of body weight, and the largest of those trials ran in children rather than in anyone choosing it.

Water added	Concentration	Draw, low to high
2 mL	4.50 mg/mL	4.4 to 6.7 units
3 mL	3.00 mg/mL	6.7 to 10.0 units

indirect evidenceDominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, Ruchała M. The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration. Front Endocrinol 2026 — tabulates self-reported online dosing patterns beside the clinical doses, stating the reported values must not be read as clinically validated, regulatory-approved or safe · retrieved 2026-08-12

The one sermorelin vial with no clean reading at all

The vial holds eighteen worked doses. Both water options put the draw between syringe lines, unlike the other documented sermorelin vial sizes.

3Read the full vial record — 3 notes

Why nine milligrams does this

The vial size and worked amount do not divide evenly with either water option. The exact answer simply falls between syringe lines.

The plunger still has to stop somewhere. The useful answer is the exact unit number, the nearest syringe line and the difference between them.

How much the missing mark actually costs

Both readings here sit in the low-to-middle teens of units, so one graduation is under a tenth of the draw. That is a real error and a small one.

It would matter far more on a vial whose draws were down at a handful of units. On this size the absence of a clean reading is an irritation rather than a hazard.

Eighteen draws from an odd fill size

This is one of the larger documented pharmacy fill sizes. No published source says how long the mixed solution keeps, so the dose count stands alone.

It also means eighteen chances to read a draw that never lands on a mark. That is a good argument for checking the figure rather than working from memory.

How do you mix it, step by step?

Wipe both stoppers with an alcohol swab and let them dry.
Draw up the water volume you picked from the table.
Let the water run slowly down the inside wall of the Sermorelin vial, rather than jetting it onto the powder.
Swirl gently until it dissolves. Shaking damages peptides.
Store it as the dispensing label directs. What happens after mixing differs by product — some labels direct against refrigerating the mixed solution at all.

What if your water volume is not on the table?

The table shows the offered water volumes. The calculator does the same arithmetic for any volume and any syringe, and shows its working line by line.

Open the Sermorelin calculator →

Where to read next about Sermorelin

The arithmetic on this page is only half the question. These are the pages that carry the other half.

Sermorelin — class, half-life and regulatory standing

No approved brand name is listed for sermorelin.

The generic calculator behind the sermorelin one

Vial strength and water volume in and the exact mark out, with sermorelin as context

Sermorelin in the regulatory changelog

A proceeding with no published outcome is entered as exactly that, including sermorelin

Per-vial tables beyond the sermorelin ones

Each guide uses the source for that peptide, not a general rule, including Sermorelin

4primary sources, each with the day we read it — open the documents used on this page