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Reconstitution · LL-37
Pick the vial, the water you added and the dose. Get the exact draw in units for the syringe in your hand.
Step 1 of 4
This vial holds 5,000 mcg in total.
U-100 insulin syringe · 1 mL · lines every 2 units · 1 unit = 0.01 mL
8.0 units on a U-100 insulin syringe · 1 mL · lines every 2 units, which is 0.08 milliliters. The draw lands on a syringe line.
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LL-37 is a peptide 37 amino acids long that your own white blood cells make. It kills bacteria by breaking open their outer membrane. It is sold for stubborn infections, for biofilms, and for gut complaints.
It has reached people twice in registered work: injected into melanoma deposits, and applied to venous leg ulcers. Neither study tested an infection. On the ulcers the two lower strengths improved healing while the highest did no better than placebo. The FDA cited animal findings of harm to male reproduction, and of tumor-promoting activity in some tissues.
Each row starts with the same 5 mg vial and changes only the amount of water. More water makes the mixture less concentrated, so the same dose uses more syringe units.
| Water added | Concentration | Per U-100 unit | Draw for 200 mcg | Nearest syringe line |
|---|---|---|---|---|
| 1 mL | 5.00 mg/mL | 50.0 mcg | 4.0 u · 0.040 mL | exactly 4 u |
| 2 mL | 2.50 mg/mL | 25.0 mcg | 8.0 u · 0.080 mL | exactly 8 u |
| 3 mL | 1.67 mg/mL | 16.7 mcg | 12.0 u · 0.120 mL | exactly 12 u |
The vial, water and dose shown here are the calculator’s starting example for LL-37. Replace them with your own values. Every result in the table is calculated from those inputs.
The only registered trial dose of LL-37 went directly into melanoma deposits, in three people at two dose levels. That is all the published human dosing evidence for LL-37.
Injecting into a tumor puts a peptide somewhere entirely different from injecting into fat. And three participants is not a group anyone can generalize an amount from.
The page also notes a skin cancer among those three. None of that stops the arithmetic below from being correct. All of it bears on whether the input is worth anything.
On leg ulcers, the two lower strengths improved healing. The highest did not differ from placebo.
So both pieces of human evidence for this peptide point the same way about going higher. On the page there is, more was not better. That is unusual enough to state plainly rather than bury.
The same amount reaches low double-digit syringe units with more water and single-digit units with less. The vial amount stays fixed; only the concentration changes.
That most-water reading is the one a syringe line can actually confirm. On a compound with this little behind its dose, taking the reading you can check costs nothing and is worth having.
This is the rare record in the group whose dose rows come from a registered trial. That trial posted its results, so the quantity is genuine and sourced. It was also measured per lesion, which is not a shape the arithmetic on this page can take.
The registry records what went into a melanoma deposit each week. Somebody with several deposits received several of those amounts in one sitting.
The trial opened and stayed open five years. It closed having enrolled four people, against a stated goal of working out the right amount. The two levels on this page are what was tried.
None of the above changes a figure in the table. The concentration is right and the draw is right. Neither has anything to say about where the contents end up.
The trial’s rhythm was weekly, for up to a couple of months. At that pace, and at these quantities, one vial covers a long stretch of calendar.
Mix 5 mg into 2 mL and one U-100 unit carries 25.0 mcg. The table shows how much peptide is in each numbered syringe line. These are conversion examples, not suggested doses.
| U-100 line | Volume | Mass (mcg) | Mass (mg) |
|---|---|---|---|
| 10 u | 0.10 mL | 250 mcg | 0.25 mg |
| 20 u | 0.20 mL | 500 mcg | 0.5 mg |
| 30 u | 0.30 mL | 750 mcg | 0.75 mg |
| 40 u | 0.40 mL | 1,000 mcg | 1 mg |
| 50 u | 0.50 mL | 1,250 mcg | 1.25 mg |
| 60 u | 0.60 mL | 1,500 mcg | 1.5 mg |
| 70 u | 0.70 mL | 1,750 mcg | 1.75 mg |
| 80 u | 0.80 mL | 2,000 mcg | 2 mg |
| 90 u | 0.90 mL | 2,250 mcg | 2.25 mg |
| 100 u | 1.00 mL | 2,500 mcg | 2.5 mg |
The math is only one part of the question. These guides cover the compound, published doses, side effects, mixing steps and supplies.