Peptides for sleep

Of these five peptides, DSIP has small studies that measured sleep directly. The other records track hormones or body-clock signals rather than sleep improvement.

Source for this answer

Source: Based on 5 compound guides · checked 2026-09-07

Three compounds—ipamorelin, CJC-1295 and sermorelin—have growth-hormone studies. Epitalon has a study of melatonin-related and body-clock signals. Those measurements do not show whether someone slept better.

DSIP’s sleep studies are small and old. Their routes and settings matter when comparing them with products sold today.

At a glance

Compounds covered

FDA-approved for this goal

Being tested for this goal

Reported use only

Five compounds, and what each study measured

DSIP studies measured sleep. The other rows explain which hormone or body-clock measurements were made and why they do not show a sleep benefit.

◆ 5 compounds coveredsources shown in each row

Compounds people take for this purpose, why they use them, what human research has measured, and where the evidence comes from.
Compound	What people take it for	What research shows	Evidence
DSIP	Sold for insomnia and for improving sleep quality.Measured in a human study	European groups gave it through the 1980s to people with insomnia and to people in alcohol and opiate withdrawal, and reported sleep normalizing. One sleep-laboratory study followed 18 chronic insomniacs aged 29 to 83. The studies were small, mostly open-label, given into a vein, and do not show an approved sleep-treatment schedule.	limited human dataDose from a human trial · no FDA label
Ipamorelin	Offered for deeper sleep based on its growth-hormone effect.Reported use only	No trial has measured sleep on this page. The two completed trials tested how quickly the gut restarted after bowel surgery, and neither beat placebo. The growth-hormone pulse is measured and real; sleep was never an endpoint.	Human trialDose from a human trial · no FDA label
CJC-1295	Sold for sleep, including in combinations with ipamorelin.Reported use only	The cited studies sampled growth hormone and IGF-I, including overnight blood measurements. They did not measure sleep quality. They used the long-acting form with a drug-affinity complex.	limited human dataDose from a human trial · no FDA label
Sermorelin	Sold by wellness clinics for sleep quality, alongside energy and body composition.Reported use only	Its trials measured height velocity in children and hormone levels in older men. Neither measured sleep. The adult study ran 14 days, so it does not answer long-term sleep questions.	limited human dataDose from a human trial · no FDA label
Epitalon	Sought for sleep and age-related changes in the body clock.Reported use only	One of its two human studies did measure a melatonin marker in urine and three clock genes, in 75 women over twenty days. That is circadian signaling, not sleep. That study did not report how participants slept.	limited human dataDose from a human trial · no FDA label

1 rests on a human study that measured something in this goal. 4 rest on reported use alone, with no study behind them.

DSIP has direct sleep measurements, with important limits

The cited DSIP studies date from the 1980s. One followed 18 people with chronic insomnia in a sleep laboratory and reported improvement after intravenous dosing.

These small studies do not show the effect of injecting DSIP under the skin. The quantity, route and study design need to stay with the reported result.

FDA listed emideltide, another name for DSIP, for a compounding-committee review in July 2026. A committee review is not a drug approval or proof that a treatment works.

Hormone readings are not sleep outcomes

The growth-hormone studies do not show a sleep benefit for ipamorelin, CJC-1295 or sermorelin. The Epitalon study measured a melatonin marker and clock genes, not sleep quality.

The sources on these four records do not report a sleep endpoint. That leaves the effect on sleep uncertain; it does not demonstrate either a benefit or a lack of benefit.

Where to go next

The grid of 32 compounds against 10 goals

32 compounds appear on at least one page here, and the grid shows on what basis each one does.

DSIP without an approved label: what exists instead

No published half-life figure was found for DSIP.

Epitalon research, dosing, and approval status

No regulator has approved epitalon; the guide separates human studies from reported use.

Where the testosterone evidence stops

Compare all 4 compounds associated with testosterone, with a source for every supported claim.

Where the skin evidence stops

Compare all 3 compounds associated with skin, with a source for every supported claim.

What ipamorelin is, how it is used, and what has been studied

Ipamorelin is a growth hormone secretagogue — selective pentapeptide (research compound).

What CJC-1295 is, how it is used, and what has been studied

CJC-1295 is a growth hormone-releasing factor analogue (research compound).

Sermorelin without an approved label: what exists instead

No published half-life figure was found for sermorelin.

Every purpose covered this way is listed on the index of goals people buy peptides for.

11primary sources, each with the day we read it — open the documents used on this page